Interaction results for

paracetamol

Severity Level

Search results may be expanded by selecting the severity level

Search Results 7

New Interaction Check Add/Remove Drug From List

Disclaimer

Generic Name

Drug Interaction

paracetamol
vs
aethanolum

Adverse Effect :
paracetamol has its toxicity increased by aethanolum

Severity Level :

Severe - The interaction between these medications may be life-threatening or may cause permanent damage. These medications are not usually used concurrently; medical intervention may be required.

Documentation Level :
Well established - There have been several published reports of this interaction. The pharmacological explanation of why the interaction occurs is well documented and understood.There are usually controlled studies that have established that the interactionexists.

Probable Mechanism :
Severe and sometimes fatal liver damage was reported in some alcoholics and chronic excessive drinkers who took only moderate doses of paracetamol. Alcoholics may be deficient in glutathione and unable to detoxify hepatotoxic metabolites. There appears to be little risk for occasional and moderate drinkers. Persistent heavy drinkers should be counselled to take lower doses or avoid paracetamol.

Actions to be Taken :
1. Avoid combination.

paracetamol belongs to the class of Paracetamol and related compounds
Paracetamol (acetaminophen) is an analgesic and antipyretic agent. Propacetamol is hydrolysed to paracetamol in the body and is likely to have the same interactions as paracetamol.

aethanolum belongs to the class of Alcohol
Alcohol reacts to varying degrees with a large number of medicinal agents.

Reference :

Zommerman HU, Maddrey WC: Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology (1995) 22 (3/Sep): 767-73

MedicinesComplete: Baxter K (ed). Alcohol + Paracetamol (Acetaminophen): Stockleys Drug Interactions. RPS Publishing, London, UK, Available from URL: http://www.medicinescomplete.com/mc [Accessed on 25/07/2008]

Sharma SC, Freely J: The influence of aspirin and paracetamol on blood concentrations of alcohol in young adults. Br J Clin Pharmacol (1996) 41467P