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  • Ketoconazole - MIMS.com
Ketoconazole

Tác Động
Description: Ketoconazole, an imidazole antifungal agent, inhibits fungal CYP450 activity, thereby decreasing ergosterol biosynthesis and inhibiting fungal cell membrane formation. It also inhibits some fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide. Ketoconazole is also a potent cortisol and aldosterone synthesis inhibitor due to its ability to block several CYP450 enzymes in the adrenal glands.
Pharmacokinetics:
Absorption: Variably absorbed from the gastrointestinal tract. Bioavailability: Decreases as gastric pH increases. Time to peak plasma concentration: Approx 1-2 hours.
Distribution: Widely distributed into tissues including inflamed joint fluid, tendons, saliva, sebum, cerumen, bile, faeces, urine, testes, skin and soft tissues; poorly penetrates the blood-brain barrier and CSF (negligible amounts). Crosses placenta and enters breast milk. Plasma protein binding: Approx 99%, mainly to albumin.
Metabolism: Extensively metabolised in the liver via oxidation, oxidative-O-dealkylation and aromatic hydroxylation by CYP3A4 isoenzyme to its inactive metabolites.
Excretion: Mainly via faeces (57%); urine (13%, 2-4% as unchanged drug). Elimination half-life: 2 hours (initial); 8 hours (terminal).


Phân loại MIMS
Thuốc kháng nấm Antifungals  /  Thuốc diệt nấm & ký sinh trùng dùng tại chỗ Topical Antifungals & Antiparasites

Phân loại ATC
D01AC08 -  ketoconazole;  Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.; 
J02AB02 -  ketoconazole;  Belongs to the class of imidazole derivatives. Used in the systemic treatment of mycotic infections.; 


Sản phẩm đang lưu hành
Antanazol [ Shinpoong Daewoo ] Dezor Kem [ Hoe Pharmaceuticals ]
Nicoziral [ Hasan-Dermapharm ]

Sản phẩm khác
Agiketo [ Agimexpharm ] Amfazol [ Ampharco U.S.A ]
Amizol [ Ampharco U.S.A ] Apo-Ketoconazole [ Apotex ]
Cadiconazol [ Cagipharm ] Comozel [ Phil Inter Pharma ]
Comozol [ Dae Hwa Pharm ] Danexil [ Labinduss ]
Etoral [ DHG Pharma ] Etoral cream [ DHG Pharma ]
Eurozol [ Hataphar ] Fungicide [ Torrent ]
Funginoc [ Torrent ] Hitoral [ Synmedic Lab ]
Katonal [ Korea United Pharm ] Kelac [ Phapharco ]
Kerifax [ Mipharmco ] Ketoconazol [ F.T. Pharma (Công ty Cổ phần Dược Phẩm 3/2) ]
Ketoconazol Mipharmco [ Mipharmco ] Ketoconazol Stada [ Stellapharm J.V. ]
Ketoconazole Daewon [ Daewon Pharm ] Ketoconazole Hovid [ Hovid ]
Ketoconazole Kolon [ Kolon ] Ketolin [ Aegis ]
Ketoxnic [ NIC Pharma ] Ketrozol [ Remedica ]
KNZ-200 [ Strides Arcolab ] Leivis [ Traphaco ]
Miniketo [ Minimed Labs ] Myzole [ Korea Arlico Pharm ]
NDC-Ketoconazol [ Nam Duoc ] Nic-Zoral [ NIC Pharma ]
Nizoral [ Janssen-Cilag ] Nizoral Shampoo [ Janssen-Cilag ]
Nizoral Viên [ Janssen-Cilag ] Nizoral viên đặt [ Janssen-Cilag ]
Opeaka [ OPV ] Phytoral [ Micro Labs ]
Profungal cream [ Dankos ] Profungal scalp solution [ Dankos ]
Profungal tab [ Dankos ] Seoul Ketoconazole [ Seoul Pharm ]
Skintoke [ Korea Eundan ] Smazol [ Yoo Young Pharm ]
Smazole [ Yoo Young Pharm ] SP-Ketop [ Shinpoong Daewoo ]
Sporoxyl [ Bangkok Lab & Cosmetic ] Tatoran [ Brown & Burk ]
Tokonazole [ Keum Kang Pharm ] Yucomy [ Y.S.P ]
Ziconal [ Pharmaniaga ]

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