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  • Maprotiline - MIMS.com
Maprotiline

Tác Động
Description: Maprotiline, a tetracyclic antidepressant and non-selective monoamine reuptake inhibitor, also inhibits norepinephrine reuptake in the presynaptic neuronal membrane. It alleviates the mood, anxiety, agitation and psychomotor retardation.
Pharmacokinetics:
Absorption: Slowly but completely absorbed from the GI tract. Absolute bioavailability: 66-70%. Time to peak plasma concentration: 8-24 hr.
Distribution: Widely distributed. Enters breast milk. Volume of distribution: 23-27 L/kg. Plasma protein binding: 88-90%.
Metabolism: Metabolised in the liver via demethylation mainly by CYP2D6 to desmethylmaprotiline; further metabolised via hydroxylation and conjugation.
Excretion: Via urine (70%) and faeces (30%). Elimination half-life: 51 hr.


Phân loại MIMS
Thuốc chống trầm cảm Antidepressants

Phân loại ATC
N06AA21 -  maprotiline;  Belongs to the class of non-selective monoamine reuptake inhibitors. Used in the management of depression.; 

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