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Mercaptopurine

Tác Động
Description: Mercaptopurine, a purine nucleoside analogue, is a pro-drug metabolised to thioguanine nucleotide (TGN). TGN inhibits de novo synthesis and interconversions of purine and is incorporated into the DNA and RNA, thereby inhibiting nucleic acid synthesis and causing cell death.
Pharmacokinetics:
Absorption: Variably and incompletely absorbed from the GI tract. Food intake may decrease bioavailability. Bioavailability: 5-37%. Time to peak plasma concentration: W/in 2 hr.
Distribution: Crosses the blood-brain barrier. Plasma protein binding: Approx 19%.
Metabolism: Extensively and rapidly metabolised in the liver via thiol methylation by thiopurine S-methyltransferase (TPMT) to methyl-mercaptopurine (inactive) and via oxidation by xanthine oxidase to 6-thiouric acid (inactive).
Excretion: Via urine (46%, as unchanged drug and as metabolites). Elimination half-life: 47 min (tab); approx 2 hr (susp).


Phân loại MIMS
Thuốc ức chế miễn dịch Immunosuppressants  /  Hóa trị gây độc tế bào Cytotoxic Chemotherapy

Phân loại ATC
L01BB02 -  mercaptopurine;  Belongs to the class of antimetabolites, purine analogues. Used in the treatment of cancer.; 


Sản phẩm khác
Catoprine [ Korea United Pharm ] Empurine [ Dabur ]
Mercaptopurine Roxane [ Roxane ] Puri-Nethol [ GlaxoSmithKline ]

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