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  • Metoclopramide - MIMS.com
Metoclopramide

Tác Động
Description: Metoclopramide blocks dopamine receptors and in higher doses, it also blocks serotonin receptors in chemoreceptor trigger zone of the CNS. It enhances the response to acetylcholine of tissue in upper GI tract causing enhanced motility and accelerated gastric emptying w/o stimulating gastric, biliary, or pancreatic secretions. It also increases lower esophageal sphincter tone.
Onset: Oral: 30-60 min; IV: 1-3 min; IM: 10-15 min.
Duration: Therapeutic: 1-2 hr.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed from the GI tract. Bioavailability: Approx 80% (oral); 74-96% (IM). Time to peak plasma concentration: Approx 1-2 hr (oral).
Distribution: Widely distributed in the body. It crosses the blood-brain barrier and placenta; enters breast milk. Volume of distribution: Approx 3.5 L/kg. Plasma protein binding: 13-30%.
Metabolism: Undergoes hepatic first-pass metabolism.
Excretion: Via urine, 85% (20% as unchanged drug and the remainder as sulfate or glucuronide conjugates or as metabolites); faeces via the bile (approx 5%). Terminal elimination half-life: Approx 4-6 hr.


Phân loại MIMS
Thuốc chống nôn Antiemetics  /  Thuốc điều hòa tiêu hóa, chống đầy hơi & kháng viêm GIT Regulators, Antiflatulents & Anti-Inflammatories



Sản phẩm đang lưu hành
Elitan [ Medochemie ]

Sản phẩm khác
Apo-Metoclop [ Apotex ] Briface-OPC [ OPC (CTCPDP OPC) ]
DHA Metoclopramide [ DHA ] H-Peran [ L.B.S ]
Meclopstad [ STADA-VN J.V ] Mefriferan [ Mebiphar ]
Metoran [ Danapha ] Perinorm [ Ipca Laboratories ]
Primperan [ Sanofi-Aventis ] Primperan oral [ Sanofi-Aventis ]
Vincomid [ Vinh Phuc ] YSPPulin [ Y.S.P ]

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