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  • Midodrine - MIMS.com
Midodrine

Tác Động
Description: Midodrine, a direct-acting sympathomimetic amine, is a prodrug which forms an active metabolite, desglymidodrine. It selectively activates the α1-adrenergic receptors of the arteriolar and venous vasculature, producing peripheral vasoconstriction and elevation of BP.
Onset: Approx 1 hr.
Duration: 2-3 hr.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Bioavailability: 93% (desglymidodrine). Time to peak plasma concentration: 30 min (midodrine); 1-2 hr (desglymidodrine).
Distribution: Poorly crosses the blood brain barrier. Plasma protein binding: <30%.
Metabolism: Metabolised in the liver and other tissues. Undergoes rapid deglycination into its active metabolite, desglymidodrine.
Excretion: Via urine (80% as desglymidodrine). Elimination half-life: 25 min (midodrine); approx 3-4 hr (desglymidodrine).


Phân loại MIMS
Thuốc co mạch Vasoconstrictors

Phân loại ATC
C01CA17 -  midodrine;  Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.; 

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