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  • Nalbuphine - MIMS.com
Nalbuphine

Tác Động
Description: Nalbuphine is a phenanthrene derivative w/ mixed opioid agonist and antagonist activity (agonist at kappa opiate receptor; partial antagonist at μ receptor). It inhibits the ascending pain pathways, alters the perception of and response to pain by binding to opiate receptors in the CNS. It also produces generalised CNS depression.
Onset: 2-3 min (IV); <15 min (IM/SC).
Duration: 3-6 hr.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 30 min (IM).
Distribution: Crosses the placenta and distributed in breast milk (small amounts). Plasma protein binding: Approx 50%.
Metabolism: Undergoes extensive first-pass metabolism in GI mucosa and liver.
Excretion: Via urine and faeces (as unchanged drug and conjugates). Elimination half-life: 5 hr.


Phân loại MIMS
Thuốc giảm đau (có chất gây nghiện) Analgesics (Opioid)

Phân loại ATC
N02AF02 -  nalbuphine;  Belongs to the class of morphinan derivative opioids. Used to relieve pain.; 

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