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Orphenadrine

Tác Động
Description: Orphenadrine is a tertiary amine antimuscarinic which exerts antiparkinsonian action by inhibiting excess central cholinergic effects that occur due to dopamine deficiency. It reduces muscle spasms possibly by its atropine-like effect on the medulla or on cerebral motor centers.
Onset: 2-4 hr (oral).
Duration: Reduction of muscle spasms: 4-6 hr.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Distribution: Plasma protein binding: 20%.
Metabolism: Almost completely metabolised in the liver into at least 8 metabolites.
Excretion: Via urine (as metabolites, 8% as unchanged drug). Elimination half-life: 14-16 hr.


Phân loại MIMS
Thuốc giãn cơ Muscle Relaxants  /  Thuốc trị bệnh Parkinson Antiparkinsonian Drugs

Phân loại ATC
N04AB02 -  orphenadrine (chloride);  Belongs to the class of anticholinergic agents, ethers chemically close to antihistamines. Used in the management of Parkinson's disease.; 

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