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  • Propranolol - MIMS.com
Propranolol

Tác Động
Description: Propranolol is a non-cardioselective β-blocker that competitively blocks β1- and β2-receptors resulting in decreased heart rate, myocardial contractility, BP and myocardial oxygen demand. It has membrane-stabilising properties.
Onset: 1-2 hr (oral).
Pharmacokinetics:
Absorption: Almost completely absorbed from the GI tract. Bioavailability: Approx 25%. Time to peak plasma concentration: Approx 1-2 hr (oral).
Distribution: Widely distributed, enters breast milk, crosses blood brain barrier and placenta. Volume of distribution: 4 L/kg. Plasma protein -binding: Approx 90%.
Metabolism: Undergoes hepatic metabolism via CYP2D6 isoenzyme, and CYP1A2 to 4-hydroxypropranolol (biologically active).
Excretion: Via urine (96-99% as metabolites and <1% as unchanged drug). Elimination half-life: Approx 3-6 hr.


Phân loại MIMS
Thuốc chẹn thụ thể bêta Beta-Blockers



Sản phẩm khác
Apo-Propranolol [ Apotex ] Avlocardyl [ AstraZeneca ]
Dorocardyl [ DOMESCO ] Inderal [ AstraZeneca ]

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