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  • Propranolol - MIMS.com
Propranolol

Tác Động
Description: Propranolol is a nonselective ß-adrenergic blocker that competitively blocks ß1 and ß2-receptors resulting in decreased heart rate, myocardial contractility, BP and myocardial oxygen demand. It has negative inotropic effects and membrane-stabilising activities but does not possess intrinsic sympathomimetic activities.
Onset: 1-2 hours (oral).
Duration: Approx 6-12 hours (immediate-release); approx. 24-27 hours (extended-release).
Pharmacokinetics:
Absorption: Almost completely absorbed from the gastrointestinal tract. Bioavailability: Approx 25%. Time to peak plasma concentration: Approx 1-2 hours.
Distribution: Widely distributed, crosses the blood brain barrier and placenta, enters the breast milk. Volume of distribution: 4 L/kg. Plasma protein binding: Approx 90%.
Metabolism: Undergoes hepatic metabolism via CYP2D6 isoenzyme, and CYP1A2 to 4-hydroxypropranolol (biologically active).
Excretion: Mainly via urine (96-99%, <1% as unchanged drug). Elimination half-life: Approx 3-6 hours.


Phân loại MIMS
Thuốc chẹn thụ thể bêta Beta-Blockers  /  Thuốc trị đau nửa đầu Antimigraine Preparations

Phân loại ATC
C07AA05 -  propranolol;  Belongs to the class of non-selective beta-blocking agents. Used in the treatment of cardiovascular diseases.; 


Sản phẩm khác
Apo-Propranolol [ Apotex ] Avlocardyl [ AstraZeneca ]
Dorocardyl [ DOMESCO ] Inderal [ AstraZeneca ]

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