Generic Medicine Info
Amoxicillin: May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort.
Hypersensitivity or history of severe allergic reactions (e.g. anaphylaxis, Stevens-Johnson syndrome) to amoxicillin or other β-lactams (e.g. penicillins, cephalosporins, carbapenems, monobactams). Suspected or confirmed infectious mononucleosis.
Special Precautions
Patient with reduced urine output, history of seizures, treated epilepsy or meningeal disorders; lymphatic leukaemia. Atopic individuals. Renal and hepatic impairment. Neonates and children. Pregnancy and lactation. Monitoring Parameters Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Evaluate the patient's allergy history before treatment initiation. Monitor renal, hepatic, and haematologic (e.g. CBC with differential) functions periodically with prolonged therapy; electrolyte balance. Assess the patient for opportunistic infection throughout therapy; signs and symptoms of anaphylaxis (during initial dose), skin rash, and antibiotic-associated diarrhoea.
Adverse Reactions
Significant: Erythematous or morbilliform rash (particularly in patients with infectious mononucleosis), Jarisch-Herxheimer reaction (in treatment of Lyme disease); aseptic meningitis, convulsion (during high doses or in renal impairment), gastrointestinal effects (e.g. diarrhoea, nausea, vomiting), fungal or bacterial superinfection (prolonged use). Rarely, prolonged prothrombin time; crystalluria (mostly with high parenteral doses in patients with reduced urine output). Blood and lymphatic system disorders: Anaemia, neutropenia, thrombocytopenia, leucopenia, agranulocytosis. Gastrointestinal disorders: Tooth discolouration (brown, yellow, or grey staining) particularly in children. Rarely, black hairy tongue. Hepatobiliary disorders: Cholestatic jaundice, hepatitis. Infections and infestations: Very rarely, mucocutaneous candidiasis. Investigations: Moderately increased AST and ALT. Nervous system disorders: Dizziness. Rarely, hyperkinesia. Psychiatric disorders: Insomnia, reversible hyperactivity, anxiety, confusion, behavioural changes. Renal and urinary disorders: Very rarely, interstitial nephritis. Respiratory, thoracic and mediastinal disorders: Bronchospasm, acute severe dyspnoea and allergic pneumonitis (large IV doses). Skin and subcutaneous tissue disorders: Rash, urticaria, pruritus.
Potentially Fatal: Hypersensitivity reactions including anaphylaxis, anaphylactoid and severe cutaneous adverse reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalised exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms); Clostridioides difficile-associated diarrhoea, Clostridioides difficile colitis.
Drug Interactions
Decreased renal tubular secretion resulting in increased and prolonged serum concentration with probenecid. Increased risk of allergic reactions (e.g. rashes) with allopurinol. Tetracyclines, chloramphenicol, macrolides, and sulfonamides may interfere with the bactericidal effect of amoxicillin. May prolong prothrombin time or increase INR when used with oral anticoagulants (e.g. warfarin, acenocoumarol). May reduce the excretion and increase the toxicity of methotrexate. May reduce the efficacy of oral contraceptives (e.g. estrogen/progesterone combination).
CIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on amoxicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 CIMS. All rights reserved. Powered by
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