Bupropion

Current or history of seizure disorder, eating disorders (e.g. bulimia or anorexia nervosa); CNS tumour, epilepsy; history of bipolar disorder (when used as an aid in smoking cessation). Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, antiepileptic drugs. Severe hepatic cirrhosis. Concomitant admin or w/in 14 days of MAOIs withdrawal.

Patient w/ bipolar disorders (in the treatment of depression); recent history of MI or unstable heart disease; other risk factors for seizures (e.g. alcohol abuse, diabetes, history of head trauma). Renal or mild to moderate hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and lightheadedness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor BP and LFT before and during treatment; monitor wkly if used w/ nicotine products. Monitor for worsening and emergence of suicidal thoughts and behaviours.

Headache, dry mouth, nausea, insomnia, dizziness, pharyngitis, constipation, agitation, anxiety, abdominal pain, tinnitus, tremor, nervousness, somnolence, irritability, vasodilation, photosensitivity, hypertonia, suicidal ideation, emotional lability, hostility, palpitation, myalgia, twitch, sweating, rash, nausea, migraine, insomnia, pharyngitis, urinary frequency or retention, hot flushes, dysphagia, flushing, anorexia, chills, facial eodema, photosensitivity, hypotension, stroke, tachycardia, gastric reflux, gingivitis, increased salivation, jaundice, mouth ulcers, stomatitis, thirst, ecchymosis, leg cramps, decreased libido, depersonalisation, dysphoria, vertigo, phlebitis, pulmonary embolism, colitis, aesophagitis, GI hemorrhage, hepatitis, intestinal perforation, pancreatitis, stomach ulcer, hyperglycaemia, hypoglycaemia, anaemia, muscle weakness, fever, rhabdomyolysis, euphoria, delirium, pneumonia, Stevens-Johnson syndrome, mydriasis, deafness, increased intraocular pressure, abnormal ejaculation, cystitis, vaginitis, and salpingitis.

Observe extreme caution w/ concurrent admin of drugs that lower seizure threshold (e.g. other antidepressants, antipsychotics, theophylline, systemic corticosteroids). Increased risk of side effects w/ levodopa or amantadine. Decreased exposure w/ CYP2B6 inducers (e.g. ritonavir, lopinavir, efavirenz). May increase exposure of CYP2D6 substrates (e.g. venlafaxine, fluoxetine, antipsychotics, β-blockers, type 1C antiarrhythmics.

Antidepressants / Antidotes, Detoxifying Agents & Drugs Used in Substance Dependence

N06AX12 - bupropion ; Belongs to the class of other antidepressants.