Citalopram: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Food Interaction Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

May be taken with or without food.

Contraindications

Congenital long QT syndrome or QT interval prolongation; bradycardia, recent acute MI, uncompensated heart failure, hypokalaemia, hypomagnesaemia. Concomitant admin or w/in 14 days of discontinuing MAOI treatment. Concomitant use w/ drug that prolong QT interval. Childn and adolescents <18 yr.

Special Precautions

May worsen depression, suicidal ideation and atypical behaviour in patients w/ psychiatric disorder. History of seizure and mania; hepatic impairment. CYP2C19 poor metabolisers. Avoid withdrawal reactions by gradual dose reduction. Pregnancy and lactation. Monitoring Parameters Closely monitor for possible depression worsening, suicidality or unusual changes in behaviour and serotonin syndrome or neuroleptic malignant syndrome (NMS)-like signs and symptoms. Periodically monitor serum electrolytes (e.g. K and Mg) before and during therapy. Monitor ECG in at-risk patients.

Adverse Reactions

Hyponatraemia (reversible); syndrome of inappropriate antidiuretic hormone secretion (SIADH); haemorrhage or bleeding; somnolence, insomnia, dizziness, asthenia, anxiety, fatigue, yawning; nausea, dry mouth, diarrhoea, dyspepsia, anorexia, vomiting, abdominal pain; sweating; decreased libido, ejaculation dysfunction, impotence in male patients, dysmenorrhoea; myalgia, arthralgia, fever; upper respiratory tract, rhinitis, sinusitis.
Potentially Fatal: Dose-dependent QT interval prolongation; torsade de pointes; ventricular tachycardia; sudden death. Increased risk of suicidal thinking and behaviour especially in childn and adolescents.

Pregnancy Category (US FDA)

Drug Interactions

May increase anticoagulant effect w/ drugs affecting haemostatis (e.g. warfarin). Increased risk of hypomania w/ sibutramine. Increased lowering seizure threshold w/ TCAs and other SSRIs.

CIMS Class

Antidepressants

ATC Classification

N06AB04 - citalopram ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.

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