Cyclizine


Generic Medicine Info
Contraindications
Premature or full-term neonates.
Special Precautions
Angle closure glaucoma; urinary retention; prostatic hypertrophy; pyloroduodenal obstruction; epilepsy, severe CV disorders; known or suspected QT interval prolongation; hypokalaemia or other electrolyte imbalances; asthma; hepatic impairment. May impair ability to drive or operate machinery. Tolerance with prolonged use. Broken or eczematous skin (topical use). Pregnancy and lactation. Elderly. Children <6 yr. Dependence.
Adverse Reactions
CNS depression e.g. drowsiness to deep sleep, lassitude, dizziness and incoordination. Headache, psychomotor impairment, dry mouth, thickening of mucous secretions, blurred vision, difficult or painful urination, constipation and increased gastric reflux. Occasionally, GI disturbances, palpitations and arrhythmias. Rashes and hypersensitivity reactions. Blood dyscrasias (rare). Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, tinnitus, hypotension and hair loss.
Drug Interactions
Enhanced sedative effects of alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, antipsychotics. Additive antimuscarinic actions with other antimuscarinic drugs and some antidepressants (TCAs and MAOIs). May mask ototoxicity symptoms caused by aminoglycoside antibiotics.
CIMS Class
Antivertigo Drugs
ATC Classification
R06AE03 - cyclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
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