May be taken with or without food.
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Stenosing peptic ulcer or pyloroduodenal obstruction. Premature infants and neonates. Lactation. Concomitant use with other antihistamine-containing medicines (including topical antihistamines).
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Patient with narrow-angle glaucoma, prostatic hypertrophy or genitourinary obstruction, urinary retention, asthma, bronchitis, COPD, CV (e.g. hypertension, ischaemic heart disease), thyroid disorder, myasthenia gravis, seizure disorders (e.g. epilepsy). Moderate to severe renal and hepatic impairment. Elderly. Pregnancy. Patient Counselling This drug may cause drowsiness or sedation, dizziness, blurred vision, cognitive and psychomotor impairment, if affected, do not drive or operate machinery. Monitoring Parameters Monitor mental alertness.
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Significant: Drug tolerance (continuous use). Rarely, eczematous reactions (topical).
Blood and lymphatic system disorders: Haemolytic anaemia, thrombocytopenia, agranulocytosis.
Cardiac disorders: Palpitations, tachycardia, extrasystoles.
Gastrointestinal disorders: Dry mouth, epigastric distress, nausea, vomiting, diarrhoea, constipation.
General disorders and administration site conditions: Fatigue.
Metabolism and nutrition disorders: Anorexia.
Nervous system disorders: Sedation, drowsiness, restlessness, dizziness, excitability (children), headache.
Psychiatric disorders: Disturbance in attention, confusion, nervousness.
Renal and urinary disorders: Urinary frequency, urinary retention, difficulty in micturition.
Respiratory, thoracic and mediastinal disorders: Thickening of bronchial secretions.
Skin and subcutaneous tissue disorders: Sensitisation reaction, photosensitivity.
Vascular disorders: Hypotension.
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May increase sedative effects of other CNS depressants (e.g. tranquilizers, hypnotics, anxiolytics). Enhanced and prolonged anticholinergic effects with MAOIs. May potentiate effects of anticholinergic agents (e.g. atropine, TCA). May diminish therapeutic effect of betahistine.
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D04AA32 - diphenhydramine ; Belongs to the class of topical antihistamines used in the treatment of pruritus.
R06AA02 - diphenhydramine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
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