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Contraindications
Severe depression, Parkinson's disease, coma, phaeochromocytoma, hypokalaemia, hypomagnesaemia, bradycardia (<55 heartbeats/min), known or suspected QT prolongation (QTc >440 millisecond in male and >450 millisecond in female). Concomitant use w/ class IA/III antiarrhythmics, macrolides, fluoroquinolones, antihistamines, certain antipsychotics, antimalarials, cisapride, domperidone, methadone, pentamidine, metoclopramide and other neuroleptics.
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Special Precautions
Patient w/ epilepsy, risk factors for cardiac arrhythmia (e.g. history of serious ventricular arrhythmia, 2nd- or 3rd-degree AV block, sinus node dysfunction, CHF, ischaemic heart disease and left ventricular hypertrophy), glaucoma, COPD, resp failure, prolactin-dependent tumours (e.g. breast cancer), risk factors for electrolyte imbalance, history of alcohol abuse. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation. Patient CounsellingThis drug may cause drowsiness, if affected, do not drive or operate machinery. Avoid exposure to direct sunlight. Monitoring Parameters Perform ECG monitoring at baseline and continue for 2-3 hr after admin. Monitor vital signs, serum Mg and K, mental status, abnormal involuntary movement scale (AIMS). Observe for dystonia, extrapyramidal side effects and temp changes.
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Adverse Reactions
Mild to moderate hypotension and tachycardia, hypovolaemia, drowsiness, restlessness, hyperactivity, anxiety, dystonia, akathisia, oculogyric crisis, dizziness, chills, laryngospasm, bronchospasm, constipation, xerostomia, blurred vision, urinary retention. Rarely, blood dyscrasias, dysphoria, convulsion, tremor.
Potentially Fatal: QT interval prolongation, torsades de pointes, cardiac arrest, ventricular tachycardia. |
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Drug Interactions
May induce electrolyte imbalance when used w/ K-wasting diuretics, laxatives and glucocorticoids. May potentiate the sedative effect of barbiturates, benzodiazepines, morphine derivatives. May cause orthostatic hypotension w/ antihypertensive agents. May inhibit the action of dopamine agonists (e.g. bromocriptine, lisuride, levodopa). Prolonged effects w/ CYP1A2 (e.g. ciprofloxacin) and CYP3A4 (e.g. ketoconazole) inhibitors.
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CIMS Class
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ATC Classification
N05AD08 - droperidol ; Belongs to the class of butyrophenone derivatives antipsychotics.
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