Should be taken on an empty stomach. Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort.
Administration
Should be taken on an empty stomach. Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort.
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Contraindications
Haemosiderosis, haemochromatosis; active peptic ulcer, inflammatory bowel disease (including regional enteritis, ulcerative colitis, intestinal strictures, diverticulae), haemoglobinopathies. Patient undergoing repeated blood transfusion. Concomitant use with dimercaprol, parenteral Fe.
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Special Precautions
Patient with history of peptic ulcer; microcytic anaemia resistant to Fe monotherapy, rheumatoid arthritis. Post-gastrectomy patient. Not indicated for the treatment of anaemia resulting from causes other than Fe deficiency. Renal and hepatic impairment. Children. Avoid use in premature infants with low vitamin E stores, until replenished. Pregnancy and lactation. Monitoring Parameters Monitor Hb, haematocrit. May consider monitoring of RBC count, RBC indices, serum ferritin, transferrin saturation, total Fe-binding capacity, serum Fe concentration, erythrocyte protoporphyrin concentration.
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Adverse Reactions
Significant: Dark stools.
Gastrointestinal disorders: Nausea, vomiting, constipation, faecal impaction (particularly in elderly), gastrointestinal discomfort, diarrhoea, dental discolouration, heartburn.
Immune system disorders: Allergic reactions.
Metabolism and nutrition disorders: Anorexia.
Renal and urinary disorders: Urinary discolouration.
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Drug Interactions
May decrease the absorption of tetracyclines, Zn, penicillamine, fluoroquinolones (e.g. ciprofloxacin, norfloxacin, ofloxacin), levodopa, entacapone, bisphosphonates, levothyroxine, mycophenolic acid. Decreased absorption with Ca, Mg and other mineral supplements; bicarbonates, carbonates, Zn, trientine, tetracyclines, antacids, colestyramine. Concomitant use with chloramphenicol delays plasma clearance, incorporation into RBC, and interferes with erythropoiesis. May decrease the hypotensive effect of methyldopa. May reduce the absorption of vitamin E.
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ATC Classification
B03AA02 - ferrous fumarate ; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia.
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