Hydromorphone


Generic Medicine Info
Contraindications
Resp depression w/o resuscitative equipment, raised intracranial pressures, head injury, convulsive disorder, status asthmaticus, paralytic ileus, acute alcoholism. Comatose patients. Severe hepatic impairment (extended-release). Lactation. Concomitant or w/in 14 days of MAOIs use.
Special Precautions
Patient w/ hypotension w/ hypovolaemia, CNS depression, toxic psychoses, delirium tremens, shock, hypothyroidism, prostatic hypertrophy and hyperplasia, severely impaired pulmonary function, adrenocortical insufficiency (e.g. Addison's Disease), kyphoscoliosis. Patient following GI surgery. Elderly. Moderate renal and hepatic impairment. Pregnancy (may cause neonatal withdrawal syndrome in prolonged use during pregnancy). Patient Counselling This drug may cause drowsiness and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor relief of pain, resp and mental status, and BP. Monitor for signs of misuse, abuse, and addiction.
Adverse Reactions
Apnoea, biliary spasm, bradycardia, confusion, constipation, dependence, difficulty w/ micturition, dizziness, drowsiness, dry mouth, dysphoria, euphoria, flushing, hallucinations, headache, hypotension, lightheadedness, miosis, mood changes, muscle rigidity, nausea, oedema, palpitation, postural hypotension, pruritus, rash, sedation, sexual dysfunction, shock, sleep disturbances, sweating, tachycardia, ureteric spasm, urinary retention, urticaria, vertigo, visual disturbances, vomiting.
Potentially Fatal: Resp depression, cardiac arrest, circulatory depression.
C Prolonged use may cause neonatal opioid withdrawal syndrome (NOWS).
Drug Interactions
Additive depressant effects w/ sedative/hypnotics, general anaesth, antipsychotics (e.g. phenothiazines), tranquilizers, and neuromuscular blockers. Reduced analgesic effect and may precipitate withdrawal symptoms w/ mixed agonist/antagonist opioid analgesics (e.g. pentazocine, nalbuphine, butorphanol, buprenorphine).
CIMS Class
ATC Classification
N02AA03 - hydromorphone ; Belongs to the class of natural opium alkaloids. Used to relieve pain.
Disclaimer: This information is independently developed by CIMS based on hydromorphone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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