Omeprazole: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Food Interaction Lab Interference Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

Delayed-release cap: Should be taken on an empty stomach. Take at least 1 hr before meals. Swallow whole, do not chew/crush. For patients w/ difficulty swallowing, cap may be carefully opened & entire contents sprinkled in a spoonful of applesauce. Swallow drug/food mixt w/o chewing immediately after prep. Drug/food mixt should not be stored for future use.
Powd for oral susp: Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before a meal.
MUPS tab: May be taken with or without food.
Cap: Should be taken with food. Take immediately before a meal.

Contraindications

Concomitant use with nelfinavir.

Special Precautions

Patient with reduced body store or risk factors for reduced vitamin B₁₂ absorption; risk of osteoporosis. Hepatic impairment. Children, elderly. Pregnancy and lactation. CYP2C19 ultrarapid metabolisers. Monitoring Parameters Rule out gastric malignancy prior to initiation of treatment. Monitor Mg concentrations prior to initiation and periodically thereafter.

Adverse Reactions

Significant: Hypomagnasaemia, cutaneous lupus erythematosus, SLE, osteoporosis-related fractures, fundic gland polyp, carcinoma, Clostridium) difficile-associated diarrhoea, interstitial nephritis, Vitamin B₁₂ deficiency (long-term therapy), gastrointestinal infection (e.g. salmonella, Campylobacter). Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, flatulence, abdominal pain. General disorders and administration site conditions: Weakness, malaise. Hepatobiliary disorders: Increased liver enzymes. Immune system disorders: Urticaria. Metabolism and nutrition disorders: Peripheral oedema. Musculoskeletal and connective tissue disorders: Back pain. Nervous system disorders: Headache, dizziness, somnolence, paraesthesia, vertigo. Psychiatric disorders: Insomnia. Respiratory, thoracic and mediastinal disorders: Cough. Skin and subcutaneous tissue disorders: Rash, dermatitis, pruritus.

Pregnancy Category (US FDA)

Drug Interactions

May decrease plasma concentrations of nelfinavir and atazanavir. Increased risk of hypomagnesaemia with diuretics. May increase plasma concentration of tacrolimus, methotrexate. May decreased absorption of itraconazole, ketoconazole, posaconazole, erlotinib. May decrease metabolism of diazepam, phenytoin, cilostazol. May reduce the antiplatelet activity of clopidogrel. May increase bioavailability of digoxin.

CIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

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