Oxycodone


Generic Medicine Info
Administration
Prolonged-release: May be taken with or without food. 160 mg tab must be taken on an empty stomach. Do not take w/ high fat meals. All strengths: Swallow whole, do not break/chew/crush. Taking broken, chewed or crushed tab leads to rapid release & absorption of a potentially fatal dose of oxycodone.
Contraindications
Resp depression, known or suspected paralytic ileus, acute abdomen, delayed gastric emptying, COPD, cor pulmonale, acute or chronic bronchial asthma, hypercarbia, chronic constipation. Concurrent admin of MAOIs or w/in 2 wk of discontinuation of use. Moderate to severe hepatic and severe renal impairment. Lactation.
Special Precautions
Patient w/ raised intracranial pressure, hypotension, hypovolaemia, toxic psychosis, biliary tract diseases, pancreatitis, inflammatory bowel disorders, prostatic hypertrophy, adrenocortical insufficiency, history of drug abuse or acute alcoholism, delirium tremens, thyroid dysfunction. Mild to moderate renal and mild hepatic impairment. Pregnancy. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor pain relief, resp and mental status, BP; signs of misuse, abuse, and addiction; signs or symptoms of hypogonadism or hypoadrenalism.
Adverse Reactions
Nausea, constipation, vomiting, resp depression, headache, pruritus, insomnia, dizziness, asthenia, somnolence, abdominal pain, chills and fever, hypotension, anorexia, diarrhoea, dyspepsia, dysphagia, anxiety, nervousness, tremor, vasodilation, cough, dyspnoea, rash.
B Prolonged use may cause neonatal opioid withdrawal syndrome (NOWS)
Drug Interactions
Potentiates the effects of tranquilisers, anaesth, hypnotics, anti-depressants, sedatives, phenothiazines, neuroleptic drugs, other opioids, muscle relaxants and antihypertensives. Concurrent admin of quinidine, a CYP2D6 inhibitor may cause an increase in serum levels and elimination half-life of oxycodone. Cimetidine and CYP3A inhibitors (e.g. ketoconazole, erythromycin) may inhibit the metabolism of oxycodone.
CIMS Class
ATC Classification
N02AA05 - oxycodone ; Belongs to the class of natural opium alkaloids. Used to relieve pain.
Disclaimer: This information is independently developed by CIMS based on oxycodone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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