Tamsulosin


Generic Medicine Info
Administration
Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush.
Orodispersible extended release tab: Should be taken with food. Place on the tongue & allow to dissolve. Then, swallow w/ saliva or water.
Cap: Should be taken with food. Take 30 min following the same meal daily. Swallow whole, do not open/chew/crush.
Contraindications
History of orthostatic hypotension. Severe renal impairment (CrCl <10 mL/min) and hepatic impairment (Child-Pugh scores >9). Concomitant use with strong CYP3A4 inhibitors in patients who are CYP2D6 poor metabolisers.
Special Precautions
Patient with myocardial dysfunction or angina pectoris, history of sulfonamide allergy. Cataract or glaucoma surgery patients. Not indicated for use in women. Patient Counselling This medicine may cause drowsiness, dizziness, blurred vision or syncope, if affected, do not drive or operate machinery. Monitoring Parameters Perform prostate cancer screening prior to initiation of therapy, then as directed. Perform digital rectal examination prior to treatment, then regularly thereafter. Monitor mental alertness, blood pressure, urinalysis at baseline; signs of relief of BPH, and lower urinary tract symptoms.
Adverse Reactions
Significant: Orthostatic hypotension, floppy iris syndrome in cataract and glaucoma surgery, hypersensitivity reactions, MI exacerbations. Cardiac disorders: Palpitations. Eye disorders: Blurred vision, visual impairment. Gastrointestinal disorders: Constipation, diarrhoea, nausea, vomiting, dry mouth. General disorders and administration site conditions: Asthenia. Nervous system disorders: Headache, dizziness. Reproductive system and breast disorders: Ejaculation disorders including retrograde ejaculation, ejaculation failure, priapism. Respiratory, thoracic and mediastinal disorders: Cough, pharyngitis, sinusitis, rhinitis, epistaxis. Skin and subcutaneous tissue disorders: Rash, pruritus, urticaria, skin desquamation, erythema multiforme, dermatitis exfoliative. Vascular disorders: Hypotension.
Drug Interactions
Increased plasma concentration with moderate or strong CYP3A4 inhibitors (e.g. cimetidine, ketoconazole) and strong CYP2D6 inhibitors (e.g. paroxetine). Decreased plasma concentration with furosemide. Increased elimination rate with diclofenac and warfarin. May enhance the hypotensive effect of anaesthetic agents and other α1-adrenoceptor blockers.
CIMS Class
Drugs for Bladder & Prostate Disorders
ATC Classification
G04CA02 - tamsulosin ; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.
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