May interfere w/ anti-platelet activity of aspirin limiting its cardioprotective effect. Increased risk of stomach & intestinal bleeding w/ phenylbutazone, indomethacin, salicylates (eg, aspirin) & other NSAIDs (eg, mefenamic acid, naproxen, diclofenac, ketoprofen), including COX-2 inhibitors (eg, celecoxib, etoricoxib); blood thinning medicines (eg, warfarin, dicumarol) or together w/ thrombolytic agents (eg, streptokinase); corticosteroids, SSRIs & anti-platelet agents. Increased toxicity of aminoglycosides (eg, amikacin, gentamicin, neomycin, tobramycin); lithium & methotrexate. Increased plasma levels w/ antacids eg, Mg hydroxide. Reduced effect of antihypertensives (eg, captopril, enalapril, losartan, telmisartan) & diuretics (eg, furosemide). May worsen heart failure, reduce kidney function & increase blood levels of cardiac glycosides (eg, digoxin). Reduced absorption w/ cholestyramine. Increased risk of kidney damage w/ ciclosporin & tacrolimus. Enhanced risk of bleeding w/ Gingko biloba
. Altered safety & efficacy w/ medicines affecting liver enzymes. May increase plasma levels of sulfonylureas (eg, gliclazide, glipizide, glimepiride) & insulin. Increased toxicity by reduced metabolism & excretion w/ probenecid. Increased risk of convulsions w/ quinolones. Increased risk of blood problems eg, hemarthrosis & hematoma w/ zidovudine.