Expanding role of SGLT2 inhibitors in T2DM and HF management
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated benefits in cardiovascular (CV) outcome trials in patients with type 2 diabetes mellitus (T2DM). A post hoc analysis of the EMPA-REG OUTCOME trial showed early reductions in CV mortality and hospitalization for heart failure (HHF) with empagliflozin, while new data from the real-world EMPRISE study continue to support empagliflozin’s cardioprotective effect in patients with a broader CV risk profile. In the EMPEROR-Reduced trial, empagliflozin treatment yielded cardiorenal benefits in patients with heart failure with reduced ejection fraction (HFrEF), regardless of T2DM status. The clinical impact of these recent findings was discussed by Professor Guntram Schernthaner of the Rudolfstiftung Hospital and Medical University of Vienna, Vienna, Austria, at the Endocrinology, Diabetes & Metabolism Hong Kong 3rd Annual Meeting (EDMHK 2020).
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