Permethrin acts on the sodium channel current that regulates the polarization of the nerve cell membrane of the louse or mite. This leads to delayed repolarization and subsequent paralysis of the louse or mite.
Pharmacology: Permethrin is a synthetic pyrethroid, which is active against a broad range of pests including lice, ticks, fleas, mites and other arthropods. Absorption studies indicants that 2% or less of the amount applied is absorbed systemically. Permethrin is detectable in residual amounts on the hair for at least 10 days following a treatment. Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites. It is primarily eliminated in the urine.