Acyclovir Stella

Acyclovir Stella

aciclovir

Manufacturer:

Stellapharm

Distributor:

HK Medical Supplies
/
Health Express
Concise Prescribing Info
Contents
Acyclovir
Indications/Uses
Treatment of HSV infections of the skin & mucous membranes including initial & recurrent genital herpes (excluding neonatal HSV & severe HSV infections in immunocompromised childn); varicella (chickenpox) & HZV (shingles) infections. Suppression (prevention of recurrences) of recurrent HSV infections in immunocompetent patients. Prophylaxis of HSV infections in immunocompromised patients.
Dosage/Direction for Use
Adult Treatment of HSV infections 200 mg 5 times daily at approx 4-hrly intervals (omit night time dose). Continue treatment for 5 days; may be extended in severe initial infections. In severely immunocompromised patients (eg, after marrow transplant) or in patient w/ impaired absorption from the gut, dose can be doubled to 400 mg. Suppression of HSV infections in immunocompetent patients 200 mg qds at approx 6-hrly intervals or 400 mg bd at approx 12-hrly intervals. Dose can be titrated down to 200 mg tds at approx 8-hrly intervals or bd at approx 12-hrly intervals. Prophylaxis of HSV infections in immunocompromised patients 200 mg qds at approx 6-hrly intervals. In severely immunocompromised patients (eg, after marrow transplant) or in patient w/ impaired absorption from the gut, dose can be doubled to 400 mg. Treatment of varicella & HZV infections 800 mg 5 times daily at approx 4-hrly intervals (omit night time dose). Continue treatment for 7 days. Paed population Treatment of HSV infections & prophylaxis of HSV infections in the immunocompromised Childn ≥2 yr Adult dose, <2 yr Half of the adult dose. Treatment of varicella infection Childn ≥6 yr 800 mg qds, 2-5 yr 400 mg qds, <2 yr 200 mg qds. Continue treatment for 5 days. Dosing may be more accurately calculated as 20 mg/kg. Max: 800 mg qds. Patients w/ renal impairment Management of HSV infections Severe renal impairment (CrCl <10 mL/min) 200 mg bd at approx 12-hrly intervals. Treatment of HZV infections Severe renal impairment (CrCl <10 mL/min) 800 mg bd at approx 12-hrly intervals, moderate renal impairment (CrCl 10-25 mL/min) 800 mg tds at approx 8-hrly intervals.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Hypersensitivity to acyclovir or valacyclovir.
Special Precautions
Closely monitor elderly patients & patients w/ renal impairment for evidence of neurological side effects. Increased risk of renal impairment w/ other nephrotoxic drugs. Prolonged or repeated courses in severely immunocompromised individuals may result in the selection of virus strains w/ reduced sensitivity, which may not respond to continued acyclovir treatment. Maintain adequate hydration in patients receiving high oral doses. Oral acyclovir should be used in paed population mainly for the treatment of non-severe skin & mucosa HSV infections. Patients w/ renal impairment. Pregnancy & lactation. Elderly.
Adverse Reactions
Headache, dizziness; nausea, vomiting, diarrhoea, abdominal pains; pruritus, rashes (including photosensitivity); fatigue, fever.
Drug Interactions
Increased plasma conc w/ drugs (eg, probenecid & cimetidine) that compete w/ active tubular secretion. Increased plasma AUCs of acyclovir & mycophenolate mofetil's inactive metabolite when co-administered in transplant patients. Increased AUC of theophylline.
MIMS Class
ATC Classification
J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Acyclovir Stella tab 800 mg
Packing/Price
35's
Form
Acyclovir Stella tab 200 mg
Packing/Price
5 × 5's
Form
Acyclovir Stella tab 400 mg
Packing/Price
35's
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Sign up for free
Already a member? Sign in