IV On demand treatment: Early haemarthrosis, muscle or oral bleeding
20-40% or IU/dL 12-24 hrly (8-24 hr for patients <6 yr) for at least 1 day, until bleeding episode is resolved or healing is achieved. More extensive haemarthrosis, muscle bleeding or haematoma
30-60% or IU/dL 12-24 hrly (8-24 hr for patients <6 yr) for 3-4 days or more until pain & acute disability are resolved. Life-threatening haemorrhages
60-100% or IU/dL 8-24 hrly (6-12 hr for patients <6 yr) until threat is resolved. Minor surgery (including tooth extraction)
30-60% or IU/dL 24 hrly (12-24 hr for patients <6 yr), at least 1 day, until healing is achieved. Major surgery
80-100% or IU/dL (pre- & post-op) 8-24 hrly (6-24 hr for patients <6 yr) until adequate wound healing, then continue therapy for at least another 7 days to maintain factor VIII activity of 30-60%. Prophylaxis
20-40 IU/kg at intervals of 2-3 days. Childn <6 yr
20-50 IU/kg 3-4 times wkly.