Symptoms: Acute Toxicity: Single oral doses of anagrelide HCl at 2500, 1500 and 200 mg/kg in mice, rats and monkeys, respectively, were not lethal. Symptoms of acute toxicity were: Decreased motor activity in mice and rats and softened stools and decreased appetite in monkeys.
There are no reports of overdosage with anagrelide HCl. Platelet reduction from anagrelide therapy is dose-related; therefore, thrombocytopenia, which can potentially cause bleeding, is expected from overdosage. Should overdosage occur, cardiac and central nervous system toxicity can also be expected.
Management: In case of overdosage, close clinical supervision of patient is required; this especially includes monitoring of the platelet count for thrombocytopenia. Dosage should be decreased or stopped, as appropriate, until the platelet count returns within the normal range.