Generic Medicine Info
Indications and Dosage
Corticosteroid-responsive dermatoses
Adult: As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions.
Child: ≥1 yr Same as adult dose. Do not use for >3 wk.
Broken skin, tuberculous or viral (e.g. herpes simplex, vaccinia, varicella) skin lesions, fungal (e.g. candidiasis, tinea) or bacterial (e.g. impetigo) skin infections, rosacea, acne, perioral dermatitis.
Special Precautions
Patient w/ seborrhoeic dermatitis, psoriasis. Childn. Pregnancy and lactation.
Adverse Reactions
Itching, burning, erythema, dryness, irritation, papular rashes; folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, and maceration. Rarely, adrenal suppression, Cushing’s syndrome.
Patient Counseling Information
Do not apply on the face, eyes, underarm, groin, breast-fold, genitals, or between the toes.
Monitoring Parameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test, and urinary free cortisol test.
Symptom: Adrenal insufficiency/hypercorticism (e.g. Cushing’s disease). Management: Symptomatic and supportive treatment. Treat electrolyte imbalance if necessary.
Description: Alclometasone, a synthetic glucocorticoid, induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the biosynthesis and activity of prostaglandins, leukotrienes, and other inflammatory mediators.
Absorption: Approx 3% is absorbed systemically after 8 hr when applied to intact skin.
Metabolism: Extensively metabolised into polar, unidentified metabolites.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Alclometasone, CID=5311000, (accessed on Jan. 20, 2020)

Store between 2-30°C.
MIMS Class
Topical Corticosteroids
ATC Classification
D07AB10 - alclometasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
Alclometasone Dipropionate Ointment. DailyMed. Source: U.S. National Library of Medicine. Accessed 09/08/2016.

Anon. Alclometasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 09/08/2016.

Buckingham R (ed). Alclometasone Dipropionate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 09/08/2016.

Joint Formulary Committee. Alclometasone Dipropionate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 09/08/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Alclometasone Dipropionate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 09/08/2016.

Disclaimer: This information is independently developed by MIMS based on Alclometasone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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