Allylestrenol


Generic Medicine Info
Indications and Dosage
Oral
Threatened miscarriage
Adult: 5 mg tid for 5-7 days, treatment may be prolonged if necessary. Gradually reduce dosage if symptoms disappear.

Oral
Recurrent miscarriage
Adult: 5-10 mg daily as soon as pregnancy is confirmed. Continue treatment for at least 1 month after the critical period.

Oral
Premature labour
Adult: For threatened premature labour: Individualise dosage. Max: 40mg daily.
Hepatic Impairment
Contraindicated.
Administration
May be taken with or without food. May be taken w/ meals if GI upset occurs.
Contraindications
Hypersensitivity. Hepatic impairment.
Special Precautions
Patient with diabetes. Pregnancy.
Adverse Reactions
Significant: Visual disturbances, proptosis or diplopia, vascular retinal ulcer; migraine.
Gastrointestinal disorders: Nausea, vomiting.
Action
Description: Allylestrenol is a synthetic progestogen structurally related to progesterone. It exhibits trophoblastic, placentotrophic, and β2-adrenergic activity with no androgenic action. Allylestrenol stimulates the hormonal effects of existing syncytiotrophoblast which are necessary for progesterone production. The pregnancy-maintaining effect is due to the stimulation of the placental function, and the stimulation of β2-adrenergic receptors prevents uterine contractility.
Chemical Structure

Chemical Structure Image
Allylestrenol_01

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 235905, Allylestrenol. https://pubchem.ncbi.nlm.nih.gov/compound/Allylestrenol. Accessed Aug. 25, 2020.

ATC Classification
G03DC01 - allylestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.
References
Malhotra N, Garg R, Malhotra N et al. Oral Allylestrenol: A Pregnancy-Supporting Progestogen. J South Asian Feder Obst Gynae. 2017;9(4):297-303. doi: 10.5005/jp-journals-10006-1517. Accessed 30/06/2020

Alyrenol (Gracia Pharmindo). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020.

Buckingham R (ed). Allylestrenol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/06/2020.

Pregnabion (Tunggal Idaman Abdi). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020.

Pregnolin (Dexa Medica). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020.

Pregtenol (Fahrenheit). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020.

Disclaimer: This information is independently developed by MIMS based on Allylestrenol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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