Amorolfine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Skin fungal infections

Adult: As 0.25% cream: Apply once daily for at least 2-3 weeks (up to 6 weeks for foot infections). Continue for 3-5 days after cure is attained.

Topical/Cutaneous
Nail fungal infections

Adult: As 5% lacquer: Paint onto the affected nail 1-2 times weekly after filing and cleansing. Continue until nail has regenerated and the affected areas are cured. Treatment duration: Approx 6 months (fingernail) or 9-12 months (toenail).

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Hypersensitivity reactions, skin irritation, erythema, pruritus, contact dermatitis, urticaria, blister. Rarely, burning sensation, severe skin reactions, nail disorder (e.g. nail discolouration, onychoclasis, onychorrhexis).

Patient Counseling Information

Avoid contact w/ eyes, ears, mucous membranes, and surrounding areas around the nail. Avoid using cosmetic lacquer or artificial nails.

Action

Description: Amorolfine, a morpholine derivative, is highly active in vitro against numerous pathogenic and opportunistic fungi. It alters fungal cell membranes by interfering w/ sterol biosynthesis.
Pharmacokinetics:
Absorption: Systemic absorption is neglible.
Distribution: Penetrates into and diffuses through the nail plate.

Storage

Store below 30°C. Protect from heat.

MIMS Class

Topical Antifungals & Antiparasites

ATC Classification

D01AE16 - amorolfine ; Belongs to the class of other antifungals for topical use.

References

Anon. Amorolfine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 20/09/2016.

Buckingham R (ed). Amorolfine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/09/2016.

Joint Formulary Committee. Amorolfine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/09/2016.

Loceryl 5% Nail Lacquer (Laboratoires Galderma). Taiwan FDA Ministry of Health and Welfare. http://www.fda.gov.tw. Accessed 20/09/2016.

Loceryl Nail Lacquer 5% (Galderma Australia Pty Ltd). Medsafe. http://www.medsafe.govt.nz/. Accessed 20/09/2016.

Disclaimer: This information is independently developed by MIMS based on Amorolfine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com