Apo-Duloxetine

Apo-Duloxetine

duloxetine

Manufacturer:

Apotex

Distributor:

Hind Wing
Concise Prescribing Info
Contents
Duloxetine HCl
Indications/Uses
Major depressive disorder. Generalised anxiety disorder.
Dosage/Direction for Use
Major depressive disorder 60 mg once daily. Generalised anxiety disorder 30-120 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Presence or history of liver disease. Concomitant use w/ MAOIs or taking MAOIs w/in the last 14 days. Concomitant use w/ potent CYP1A2 inhibitor eg, fluvoxamine or ciprofloxacin.
Special Precautions
Allergies to any other medicines or substances eg, foods, preservatives, dyes. Presence or history of any medical conditions especially glaucoma, high BP, heart problems, kidney problems, history of seizures, DM. Patient or family history of bipolar disorder, depression or suicide. Surgery or anaesth. Currently receiving or planned dental treatment. Alcohol consumption. Do not start treatment in patient receiving linezolid; wait until 24 hr after last dose of linezolid before starting duloxetine treatment. Stop taking duloxetine at least 5 days before starting a MAOI. Monitor for any signs of suicidal thoughts or other mental/mood changes. Monitor for signs of liver damage. May impair ability to drive & use machines. Pregnancy & lactation. Should not be used in childn & adolescents <18 yr.
Adverse Reactions
Dry mouth, mouth ulcers, thirst, bad taste; burping or belching, indigestion, stomach pain, nausea, vomiting; constipation, diarrhoea, flatulence; bad breath; loss of appetite, wt loss; headache; trouble sleeping; dream abnormalities; drowsiness; feeling tired; sexual problems; dizziness; tremor; blurred vision; feeling anxious, agitated or restless; confusion & attention problems; tingling & numbness of hands, face, mouth & feet; yawning or throat tightness; difficulty urinating, urinating frequently or needing to urinate at night; irregular heart beat; hot & cold sweats; sore ears, sore throat; ringing in ears; muscle pain, stiffness or twitching; walking problems; flushing; skin rash; restless legs.
Drug Interactions
Potential interaction w/ MAOIs; antidepressants/anxiolytics including tryptophan; strong painkillers eg, tramadol, pethidine; triptans eg, sumatriptan, zolmitriptan; tolterodine; flecainide or propafenone; thioridazine; herbal medicines eg, St. John's Wort; warfarin.
MIMS Class
Antidepressants
ATC Classification
N06AX21 - duloxetine ; Belongs to the class of other antidepressants.
Presentation/Packing
Form
Apo-Duloxetine enteric cap 30 mg
Packing/Price
30's
Form
Apo-Duloxetine enteric cap 60 mg
Packing/Price
30's
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