Intracameral use. One vial for single-use only.
Posology: Adults: The recommended dose is 0.1 ml of reconstituted solution (see Special precautions for disposal and other handling under Cautions for Usage), i.e. 1 mg of cefuroxime.
DO NOT INJECT MORE THAN THE RECOMMENDED DOSE (see Overdosage).
Paediatric population: The optimal dose and the safety of APROKAM have not been established in the paediatric population.
Elderly: No dose adjustment is necessary.
Patients with hepatic and renal impairment: Considering the low dose and the expected negligible systemic exposure to cefuroxime using APROKAM, no dose adjustment is necessary.
Method of administration: APROKAM must be administered after reconstitution by intraocular injection in the anterior chamber of the eye (intracameral use), by an ophthalmic surgeon, in the recommended aseptic conditions of cataract surgery. Only sodium chloride 9 mg/ml (0.9 %) solution for injection must be used when reconstituting APROKAM (see Special precautions for disposal and other handling under Cautions for Usage).
After reconstitution, APROKAM should be inspected visually for particulate matter and discoloration prior to administration.
Slowly inject 0.1 ml of the reconstituted solution into the anterior chamber of the eye at the end of the cataract surgery.
For instructions on reconstitution of the medicinal product before administration, see Special precautions for disposal and other handling under Cautions for Usage.