Atropine Sulfate Martindale

Atropine Sulfate Martindale





Medreich Kali
International Med
Concise Prescribing Info
Atropine sulfate
Reduction of saliva secretion before general anaesth. Restores normal heartbeat during cardiac arrest. Antidote to some insecticides & in mushroom poisoning. In combination w/ other drugs to reverse the effect of muscle relaxants used during surgery.
Dosage/Direction for Use
Pre-op medication Adult IV 300-600 mcg immediately before anaesth induction. IM or SC 300-600 mcg 1 hr before anaesth induction. Childn SC Administer 30 min before anaesth induction. Childn 41 kg 600 mcg, 32 kg 500 mcg, 20-27 kg 400 mcg, 12-16 kg 300 mcg, 7-9 kg 200 mcg, <3 kg 100 mcg, premature infant 65 mcg. If IM route, administer 30-60 min before anaesth induction. Childn >1 yr Alternative dosage: 10-20 mcg/kg 30-60 min before anaesth induction. Antidote to cholinesterase inhibitors Adult 2 mg preferably IV. Childn 50 mcg/kg IV or IM, repeat dose every 5-10 min until signs of atropinisation appear. Antidote to organophosphate pesticides & in mushroom poisoning Adult 2 mg IV or IM. Childn 50 mcg/kg IV or IM, repeat dose every 10-30 min until muscarinic signs & symptoms subside. Reversal of effects of non-depolarising muscle relaxants Adult 0.6-1.2 mg IV in conjunction w/ neostigmine methylsulfate. CPR Adult 3 mg IV once. Childn 20 mcg/kg IV once. Bradycardia, particularly if complicated by hypotension Initially 300 mcg IV, increase to 1 mg if necessary.
Hypersensitivity. Closed-angle glaucoma; enlarged prostate; myasthenia gravis; pyloric stenosis; paralytic ileus; ulcerative colitis.
Special Precautions
Urinary difficulties; heart failure; heart attack; heart transplant; COPD; overactive thyroid; high BP; fever; diarrhoea; reflux oesophagitis. Pregnancy & lactation.
Adverse Reactions
Drowsiness, blurred vision, dry mouth w/ difficulty swallowing, thirst, dilation of the pupils, flushing, dryness of the skin, slow heart beat followed by fast heartbeat, palpitations, difficulty in passing urine or constipation; vomiting; confusion especially in the elderly or severe confusion; coughing & bringing up phlegm (bronchial plugs); restlessness; hallucinations; arrhythmias; AV block after heart transplantation; fever.
Drug Interactions
Antipsychotics or antidepressants; amantadine; antihistamines; disopyramide, mexiletine; ketoconazole; medicines that need to be dissolved slowly in the mouth.
ATC Classification
A03BA01 - atropine ; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
Atropine Sulfate Martindale soln for inj 600 mcg/mL
10 × 1's
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