Atropine Sulfate Martindale

Atropine Sulfate Martindale

atropine

Manufacturer:

Martindale

Distributor:

Medreich Kali
/
International Med
Full Prescribing Info
Contents
Atropine sulfate.
Description
Each mL contains 600 micrograms atropine sulfate (0.06% w/v).
Excipients/Inactive Ingredients: The other ingredients are sodium chloride and water for injections. It may also include sodium hydroxide and sulfuric acid.
Indications/Uses
Atropine Solution for injection belongs to a group of medicines known as anticholinergics. These medicines are often used: before general anaesthesia to reduce saliva secretions; to restore normal heartbeat during a cardiac arrest; as an antidote to some insecticides and in mushroom poisoning; in combination with other drugs to reverse the effect of muscle relaxants used during surgery.
Dosage/Direction for Use
The nurse or doctor will give the injection.
The doctor will decide the correct dosage and how and when the injection will be given.
Pre-operative medication: Adults: By the intravenous route: 300 - 600 micrograms immediately before induction of anaesthesia.
By the intramuscular or subcutaneous route: 300 - 600 micrograms, one hour before induction of anaesthesia.
Children: By the subcutaneous route 30 minutes before induction of anaesthesia.
Premature infants: 65 micrograms.
Children up to 3kg: 100 micrograms.
Children 7-9kg: 200 micrograms.
Children 12-16kg: 300 micrograms.
Children 20-27kg: 400 micrograms.
Children 32kg: 500 micrograms.
Children 41kg: 600 micrograms.
By the intramuscular route 30-60 minutes before induction of anaesthesia.
Alternative dosage statement for children over 1 year: 10-20 micrograms/kg 30-60 minutes before induction of anaesthesia.
As an antidote to cholinesterase inhibitors: Adults: 2mg, preferably IV.
Children: 50 micrograms/kg IV or IM.
Repeat dose every 5-10 minutes until signs of atropinisation appear.
As an antidote to organophosphate pesticides and in mushroom poisoning: Adults: 2mg IV or IM.
Children: 50 micrograms/kg IV or IM.
Repeat dose every 10-30 minutes until muscarinic signs and symptoms subside.
Reversal of effects of non-depolarising muscle relaxants: Adults: 0.6 - 1.2 mg given IV in conjunction with neostigmine methyl-sulfate.
In cardiopulmonary resuscitation: Adults: 3mg IV once.
Children: 20 micrograms/kg IV once.
In arrhythmias: Bradycardia, particularly if complicated by hypotension, 300 micrograms IV initially, increasing to 1mg if necessary.
Method of administration: Atropine sulfate 600 micrograms in 1ml solution for injection is administered by intravenous, intramuscular or subcutaneous injection.
Overdosage
Since the injection will be given to by a doctor or nurse, it is unlikely that the patient will be given too much.
If the patient thinks he/she has been given too much, or the patient begins to feel his/her heart beating very fast, he/she is breathing quickly, has a high temperature, feels restless, confused, has hallucinations, or loses co-ordination he/she must tell the person giving the injection immediately.
Contraindications
The patient should NOT be given Atropine Solution for injection if: He/she is allergic to Atropine sulfate or to any of the other ingredients of this medicine (listed in Description).
He/she suffers from closed-angle glaucoma (a condition that affects the eyes).
He is a man with an enlarged prostate.
He/she suffers from myasthenia gravis (weakness of breathing muscles).
He/she suffers from pyloric stenosis (a narrowing of the opening that takes away food from the stomach).
He/she suffers from paralytic ileus (the intestine stops functioning properly).
He/she suffers from ulcerative colitis - a disease of the colon and rectum.
Special Precautions
Talk to the doctor, pharmacist or nurse before being given Atropine Solution for injection if: The patient has urinary difficulties.
The patient has heart failure.
The patient has had a heart attack.
The patient has had a heart transplant.
The patient has chronic pulmonary obstructive disease (a condition where the airflow to the lungs is restricted and the patient may cough and feel breathless).
The patient has an overactive thyroid.
The patient has high blood pressure.
The patient has a fever.
The patient has diarrhoea.
The patient has reflux oesophagitis (heartburn).
Driving and using machines: The patient should not drive or use machinery if he/she is affected by the administration of Atropine Solution for injection.
Use In Pregnancy & Lactation
If the patient is pregnant or breast-feeding, thinks she may be pregnant or is planning to have a baby, the patient should ask the doctor or pharmacist for advice before she is given this medicine.
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects have been reported.
Contact the doctor or nurse immediately if the patient gets any of the following: Sudden life-threatening allergic reaction such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing.
Other Side effects include: drowsiness, blurred vision, dry mouth with difficulty swallowing, thirst, dilation of the pupils, flushing, dryness of the skin, slow heart beat followed by fast heart beat, palpitations (the patient is aware of his/her heart beating), difficulty in passing urine or constipation, vomiting, confusion especially in the elderly or severe confusion, coughing and bringing up phlegm (bronchial plugs), restlessness, hallucinations, changes in the way the heart beats (arrhythmias), heart condition (atrioventricular block) after heart transplantation, fever.
If the patient thinks this injection is causing him/her any problems, or the patient is at all worried, he/she should talk to the doctor, nurse or pharmacist.
Drug Interactions
Tell the doctor, pharmacist or nurse if the patient is taking, has recently taken or might take any other medicines including medicines obtained without prescription.
Other medicines which may interact with Atropine Solution for injection are: medicines to treat psychosis or depression; amantadine (a medicine for Parkinson's disease); antihistamines (medicines used to treat hayfever and allergies); medicines to regulate the heart (disopyramide and mexiletine); ketoconazole (a medicine to treat fungal infections); medicines that are taken by allowing them to dissolve slowly in the mouth - atropine may cause the mouth to become dry, making it more difficult for these medicines to dissolve.
Storage
Do not store above 25°C.
Keep the ampoule in the outer carton in order to protect from light.
ATC Classification
A03BA01 - atropine ; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Soln for inj (amp) 600 mcg/mL (clear, colourless solution) x 10's
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