Special Instructions for Use, Handling and Disposal: Avastin Roche infusions should not be administered or mixed with dextrose or glucose solutions (see Incompatibilities as follows).
Do not administer as an intravenous push or bolus.
Avastin Roche should be prepared by a healthcare professional using aseptic technique.
Withdraw the necessary amount of bevacizumab and dilute to the required administration volume with 0.9% sodium chloride solution. The concentration of the final bevacizumab solution should be kept within the range of 1.4-16.5 mg/ml.
Discard any unused portion left in a vial, as the product contains no preservatives. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
Avastin Roche is not formulated for intravitreal use.
Incompatibilities: No incompatibilities between Avastin Roche and polyvinyl chloride or polyolefin bags have been observed. A concentration-dependent degradation profile of Avastin Roche was observed when diluted with dextrose solutions (5%).
Disposal of unused/expired medicines: The release of pharmaceuticals in the environment should be minimised. Medicines should not be disposed of via wastewater and disposal through household waste should be avoided.