Not recommended in severe active CNS lupus; severe active lupus nephritis; HIV; history of, or current, hepatitis B or C; hypogammaglobulinaemia or IgA deficiency; history of major organ transplant or hematopoietic stem cell/marrow transplant or renal transplant. Concomitant use w/ other B-cell targeted therapy or IV cyclophosphamide. Infusion &/or hypersensitivity reactions. Increased risk of infections, malignancies & lymphoproliferative disorders. Do not administer live vaccines 30 days prior to or concurrent w/ therapy. Reports of psychiatric disorders (depression, suicidal ideation & behaviour including suicides); progressive multifocal leukoencephalopathy. Patients w/ active or latent TB. Patients w/ severe renal impairment. Women of childbearing potential must use effective contraception during treatment & for at least 4 mth after the last treatment. Pregnancy & lactation. Elderly ≥65 yr. Powd for concentrate for soln for infusion:
Do not administer as IV bolus. Childn <5 yr. Soln for inj:
Childn <18 yr.