Besifloxacin


Generic Medicine Info
Indications and Dosage
Ophthalmic
Bacterial conjunctivitis
Adult: As 0.6% susp: Instill 1 drop onto affected eye(s) tid, 4-12 hours apart, for 7 days.
Child: >1 year Same as adult dose.
Special Precautions
Children. Pregnancy and lactation.
Adverse Reactions
Significant: Hypersensitivity reactions, fungal or bacterial superinfection (prolonged use).
Eye disorders: Conjunctival redness, blurred vision, eye pain, eye irritation, eye pruritus.
Nervous system disorders: Headache.
Patient Counseling Information
Avoid use of contact lenses.
Action
Description: Besifloxacin is a fluoroquinolone antibacterial which acts by inhibiting DNA synthesis in susceptible organisms via inhibition of both topoisomerase IV (essential during bacterial cell division) and DNA gyrase (essential for bacterial reproduction).
Pharmacokinetics:
Excretion: Elimination half-life: Approx 7 hours.
Chemical Structure

Chemical Structure Image
Besifloxacin

Source: National Center for Biotechnology Information. PubChem Database. Besifloxacin, CID=10178705, https://pubchem.ncbi.nlm.nih.gov/compound/Besifloxacin (accessed on Jan. 21, 2020)

Storage
Store between 15-25°C. Protect from light.
ATC Classification
S01AE08 - besifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
References
Anon. Besifloxacin. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 05/04/2018.

Anon. Besifloxacin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/04/2018.

Besivance Suspension (Bausch & Lomb Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/04/2018.

Buckingham R (ed). Besifloxacin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/04/2018.

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