Adverse reactions occur in approximately 10% of the patients and are usually dose-related.
Adverse reactions related to all use of metoprolol are shown below according to system organ class and frequency.
The following definitions of frequencies are used: Very common (≥1/10), common (≥1/100 and <1/10), uncommon (≥1/1000 and<1/100), rare (≥1/10000, <1/1000) and very rare (<1/10000), not known (cannot be estimated from the available data).
Common: Bradycardia, palpitations. Uncommon: Chest pain, transient aggravation of heart failure, cardiogenic shock in patients with acute myocardial infarction. Rare: Prolonged AV conduction time, cardiac arrhythmias.
Blood and Lymphatic System Disorders:
Nervous System Disorders:
Common: Headache, dizziness. Uncommon: Paraesthesiae.
Rare: Visual disturbances, dry and/or irritated eyes. Not Known: Conjunctivitis.
Ear and Labyrinth Disorders:
Respiratory, Thoracic and Mediastinal Disorders:
Common: Shortness of breath upon exercise. Uncommon: Bronchospasm in patients with bronchial asthma or asthmatic problems. Not Known: Rhinitis.
Common: Abdominal pain, nausea, vomiting, diarrhoea, constipation. Rare: Taste disturbances. Not Known: Dry mouth.
Skin and Subcutaneous Tissue Disorders:
Uncommon: Hypersensitivity reactions on the skin. Rare: Aggravated psoriasis, photosensitivity reactions, hyperhidrosis, hair loss.
Musculoskeletal and Connective Tissue Disorders:
Not Known: Muscular cramps, arthralgia.
Common: Peripheral coldness in extremities. Rare: Syncope. Not Known: Gangrene in patients with severe peripheral vascular disorders.
General Disorders and Administration Site Conditions:
Very Common: Fatigue. Uncommon: Oedema, weight gain.
Rare: Elevated transaminases. Not Known: Hepatitis.
Reproductive System and Breast Disorders:
Rare: Reversible libido dysfunction.
Uncommon: Depression, nightmares, sleep disturbances. Rare: Memory impairment, confusion, nervousness, anxiety, hallucinations. Not Known: Impaired concentration ability.