Brolucizumab


Generic Medicine Info
Indications and Dosage
Intravitreal
Neovascular (wet) age-related macular degeneration
Adult: 6 mg once monthly for the 1st 3 doses; followed by 6 mg once every 2-3 months, according to response. In patients without disease activity: May consider treatment interval of every 3 months. In patients with disease activity: May consider treatment interval of every 2 months. May further adjust treatment interval based on disease activity. Instruction prior to administration may vary among individual products and between countries (refer to specific product guidelines).
Contraindications
Active or suspected ocular or periocular infections, active intraocular inflammation.
Special Precautions
Patient with poorly controlled glaucoma, risk factors for retinal pigment epithelial tear (e.g. large and/or high pigment epithelial retinal detachment); retinal detachment or macular hole; history of stroke, TIA or MI within the last 3 months.
Adverse Reactions
Significant: Endophthalmitis, retinal detachment, intraocular inflammation, traumatic cataract, acute and sustained increases in intraocular pressure, retinal vasculitis or retinal vascular occlusion, antibody development, non-ocular haemorrhages; risk of arterial thromboembolic events (e.g. stroke, MI).
Eye disorders: Reduced visual acuity, vitreous floaters, conjunctival haemorrhage, uveitis, iritis, vitreous detachment, retinal tear, eye pain, blurred vision, conjunctivitis, retinal pigment epithelial tear, corneal abrasion, punctate keratitis.
Immune system disorders: Hypersensitivity (e.g. rash, pruritus, urticaria, erythema).
Patient Counseling Information
This drug may cause temporary visual disturbances, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor intraocular pressure using tonometry and optic nerve head perfusion immediately after administration. Evaluate for signs and symptoms of endophthalmitis (e.g. eye pain or redness, photophobia, blurred vision), retinal detachment or thromboembolic events.
Overdosage
Symptoms: Increased intraocular pressure. Management: Monitor and initiate appropriate treatment.
Action
Description: Brolucizumab, a recombinant humanised monoclonal antibody vascular endothelial growth factor (VEGF) inhibitor, binds with high affinity to 3 major isoforms of VEGF-A. This results in suppressed endothelial cell proliferation, reduced neovascularisation, and decreased vascular permeability.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 24 hours (free brolucizumab).
Metabolism: Expected to be metabolised via proteolysis (free brolucizumab).
Excretion: Elimination half-life: 4.4 ± 2 days.
Storage
Store between 2-8°C. Do not freeze. Protect from light. Unopened vial or pre-filled syringe may be stored below 25°C for up to 24 hours prior to use.
ATC Classification
S01LA06 - brolucizumab ; Belongs to the class antineovasculatisation agents. Used in the management of neovascular macular degeneration.
References
Anon. Brolucizumab. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/07/2021.

Beovu 120 mg/mL Solution for Injection in Pre-Filled Syringe; Beovu 120 mg/mL Solution for Injection (Novartis Pharmaceuticals UK Limited). MHRA. https://products.mhra.gov.uk. Accessed 02/07/2021.

Beovu Injection Solution (Novartis Pharmaceuticals Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/07/2021.

Buckingham R (ed). Brolucizumab. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/07/2021.

Joint Formulary Committee. Brolucizumab. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/07/2021.

Pagenax 120 mg/mL Solution for Injection (Novartis Corporation [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/07/2021.

Disclaimer: This information is independently developed by MIMS based on Brolucizumab from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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