Buclizine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Prophylaxis of motion sickness

Adult: As hydrochloride: 25 or 50 mg given 30 min before travelling, repeated after 4-6 hr, if necessary.

Oral
Pruritic skin disorders

Adult: As hydrochloride: 25-50 mg daily.

Oral
Nausea and vomiting

Adult: As hydrochloride: 25 or 50 mg tid.

Oral
Migraine

Adult: As hydrochloride: 12.5 mg taken as soon as symptoms arise.
Child: 10-14 yr: 6.25 mg at the start of the symptoms. >14 yr: follow adult dose.

Administration

Should be taken with food. Take w/in 30 min before meals.

Contraindications

Hypersensitivity; neonates.

Special Precautions

Driving or operating machinery; open-angle glaucoma; urinary retention; prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment; pregnancy.

Adverse Reactions

Drowsiness, dizziness, incoordination; blurred vision; urinary retention; vomiting; rash; dry mouth; headache, nausea, epigastric pain, wt gain and diarrhoea.

Drug Interactions

Potentially Fatal: Effect of alcohol, sedatives and other CNS depressants potentiated.

Action

Description: Buclizine is a piperazine antihistamine with antimuscarinic and moderate sedative properties. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.

MIMS Class

Antihistamines & Antiallergics

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