Buprenorphine+naloxone - oral

Patient Medicine Information
Why do I need this medicine?
Buprenorphine and Naloxone are combined together in this medicine.

This medicine is used to treat addiction to opioid drugs such as morphine and heroin.

Buprenorphine+Naloxone is meant to be used as part of a total drug addiction care programme that includes counselling and social support.
How do I take this medicine?
Take Buprenorphine+Naloxone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine is available as a sublingual tablet or buccal film.

If you are taking the sublingual tablet, do not swallow, chew or crush the tablet. It must be placed under your tongue until it melt.

If you are taking the buccal film, do not cut or tear the film. It must be placed between the gums and the cheek. Do not chew or swallow the film.

Buprenorphine+Naloxone must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:

- severe breathing problems
- severe liver disease
- alcoholism or alcohol withdrawal
as this medicine may not be suitable for you.

DO NOT take Buprenorphine+Naloxone with medicines used to treat alcohol or drug dependence such as naltrexone or nalmefene.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:

- blocked bowel
- biliary tract disorder
- depression
- head injury
- liver disease
- thyroid problems
- prostate enlargement
- breathing problems
- Addison's disease (disorder of the adrenal glands)
- alcohol dependence

Let your doctor know if you are pregnant or breastfeeding.

For as long as you are taking this medicine, you may need to have regular liver function test to check your body's response to the medicine. Your doctor will advise you about how often you need to have these test. Breathing and mental status, symptoms of withdrawal and signs of addiction, abuse or misuse may also be monitored while you are being treated with Buprenorphine+Naloxone.
What side effects could I experience?
Buprenorphine+Naloxone may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

This medicine may cause any of the following side effects: headache, weakness, difficulty sleeping, anxiety or depression, nausea, vomiting, constipation, excessive sweating and back pain.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:

- medicines for drug dependence e.g. naltrexone, nalmefene
- medicines for depression e.g. isocarboxacid, phenelzine, tranylcypromine
- medicines for fungal infection e.g. ketoconazole, itrazonazole
- antibiotics e.g. erythromycin
- medicines for HIV infection e.g. atazanavir, ritonavir, indinavir, efavirenz
- medicine for epilepsy (fits or seizures) e.g. carbamazepine, phenytoin, phenobarbital
- medicines for TB (lung infection known as tuberculosis) e.g. rifampicin

This list does not include all medicines that may interact with Buprenorphine+Naloxone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from freezing and moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on buprenorphine+naloxone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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