Known hypersensitivity to ergot alkaloids, caffeine, or any other components of the formulations (see Description).
Pregnancy and breast-feeding (see Use in Pregnancy & Lactation).
Impaired peripheral circulation, obliterative vascular disease, coronary heart disease, inadequately controlled hypertension, septic conditions, shock.
Severe renal or hepatic impairment.
Hemiplegic or basilar migraine.
Concomitant treatment with macrolide antibiotics, HIV protease or reverse transcriptase inhibitors, azole antifungals (see Interactions).
Concomitant treatment with vasoconstrictor agents (including ergot alkaloids, sumatriptan and other 5HT receptor agonists) (see Interactions).