Clotrimazole 1% w/v lotion.
A clear colourless lotion.
Pharmacology: Pharmacodynamics: Clotrimazole is a broad spectrum imidazole with potent anti-fungal properties against dermatophytes, including Epidermophytes, Microsporum, Trichophyton spp. and Malassezia furfur and Candida species. It permeates the chitin of the fungal cell wall and increases the membrane permeability to various intracellular substances. Most strains of dermatophytes and Candida species are inhibited by concentrations of less than 2 mcg/ml.
Pharmacokinetics: Clotrimazole is effective against a variety of fungi including Epidermophytes yeasts, Microsporum, Trichophyton spp., and Malassezia furfur. When applied topically, clotrimazole penetrates the epidermis. Actinomycetes, gram-positive bacteria, certain anaerobes (such as Bacteroides fragilis) and Trichomonas vaginalis are also inhibited. Absorption of clotrimazole is less than 0.5% after application to the intact skin. The small amount absorbed is metabolized in the liver to inactive compounds and excreted in the bile and urine.
Topical fungal treatment of tinea corporis, tinea cruris, tinea pedis, tinea versicolor and cutaneous candidiasis.
Wash and dry affected area. Apply sparingly to the affected parts and surrounding skin areas and rub in twice daily, morning and evening. Regular application is essential for successful treatment. Treatment should be continued for 2 weeks after all clinical signs have disappeared. Attention to hygiene is important in the management of fungal diseases, particularly of the folds and the feet. If no improvement is seen after 4 weeks, diagnosis should be reviewed.
After topical application to the skin clotrimazole penetrates the epidermis and deeper layers of the skin but less than 0.5% of the dose is absorbed systemically. No information is available concerning overdosage in human beings following topical application.
Hypersensitivity to clotrimazole, or any component in the preparation.
If irritation or sensitivity occurs, treatment should be discontinued. Do not use on children under 2 years of age except under the advice and supervision of a doctor. Avoid contact with eyes and mucous membranes (for external use only). Advise to consult doctor if no improvement is seen in 4 weeks (for athlete's foot) or 2 weeks (for jock itch). Not for ophthalmic use.
In the first trimester of pregnancy, clotrimazole should only be used when considered essential to the welfare of the patient. It is not known whether clotrimazole is excreted in breast milk or whether it has a harmful effect in the newborn.
In a small fraction of recipients, clotrimazole when applied topically may cause stinging, erythema, oedema, vesication, desquamation, pruritus and urticaria.
Keep container well closed. Protect from strong light. Store below 30°C.
Recommended shelf-life: 2 years.
D01AC01 - clotrimazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Lotion 1% (clear colourless) x 10 mL.