Initially 8 mg once daily. May be increased to 16 mg once daily. Max: 32 mg once daily. Childn & adolescent 6 to <18 yr, weighing ≥50 kg
Initially 4 mg once daily, can be increased to 8 mg once diaily then 16 mg if needed; weighing <50 kg
Initially 4 mg once daily, can be increased to 8 mg once daily. Patients w/ intravascular vol depletion
Initially 4 mg. Renal impairment
Initially 4 mg. Mild to moderate hepatic impairment
Initially 4 mg. Heart failure
Initially 4 mg once daily. May be increased to 32 mg once daily (max dose), or achieve highest tolerated dose by doubling the dose at intervals of at least 2 wk.