Captopril + hydrochlorothiazide - oral

Patient Medicine Information
Why do I need this medicine?
Captopril and Hydrochlorothiazide are combined in this medicine.

This medicine helps to keep your blood pressure under control.
How do I take this medicine?
Take Captopril + Hydrochlorothiazide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine should be taken on an empty stomach, at least 1 hour before meals. Try to take it at the same time each day.

Captopril + Hydrochlorothiazide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Captopril + Hydrochlorothiazide if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or similar medicines such as sulfonamide-containing drugs.

Alert your doctor if you have the following conditions:
  • previously experienced a serious allergic reaction (e.g. swelling of the face, lips, and throat) due to an unknown reason or a family history
  • inability to pass urine
  • severe kidney disease
  • severe liver disease
as Captopril + Hydrochlorothiazide may not be suitable for you.

Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Captopril + Hydrochlorothiazide, alert your doctor immediately. This medicine may cause harm to your unborn child. You must use proven birth control methods while taking this medicine.

Do not take Captopril + Hydrochlorothiazide with aliskiren (medicine for high blood pressure) if you have diabetes and severe kidney disease.

Do not take this medicine if you are currently taking or have taken sacubitril (medicine for high blood pressure) in the last 36 hours.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • diabetes
  • gout (abnormal metabolism of uric acid)
  • high level of cholesterol in the blood
  • electrolyte imbalance (imbalance of essential minerals in the body)
  • immune system diseases affecting collagen
  • systemic lupus erythematosus or SLE (autoimmune disease that causes inflammation)
  • heart disease e.g. narrowing of the valves of the heart, hypertrophic cardiomyopathy (abnormally thick heart muscle)
  • mild to moderate liver disease
  • mild to moderate kidney disease or undergoing dialysis
Let your doctor know if you are breastfeeding.

Be sure to check with your doctor or pharmacist before giving this medicine to the elderly. Elderly people may be more sensitive to the side effects.

If you are of a Black race, Captopril + Hydrochlorothiazide may be less effective. Inform your doctor if you are taking this medicine.

If you are going to have an operation or certain laboratory tests, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure regularly.
  • Routine tests (e.g. kidney function, electrolyte levels, complete blood count) may be done while you are being treated with Captopril + Hydrochlorothiazide. Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring for signs of certain allergic reactions or skin reactions (e.g. appearance of moles or lesions) may also be needed.
What lifestyle changes can I make to improve my blood pressure?

Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.

Try to keep stress levels under control as stress will cause your blood pressure to go up.
What side effects could I experience?
Captopril + Hydrochlorothiazide may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

You may experience dizziness when getting up from a sitting or lying down position, especially if you are taking Captopril + Hydrochlorothiazide for the first time. This is common and should disappear gradually as you get used to this medicine. It will help if you get up slowly from a sitting or lying position.

This medicine may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps.

Other side effects may include any of the following: headache, cough, nausea, vomiting, diarrhoea, constipation, dry mouth, stomach pain, loss of taste perception, weakness, muscle pain, and hair loss.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swollen face, eyes, tongue or throat
  • yellowing of the skin or eyes, stomach pain, dark coloured urine, tiredness, swelling in the legs and ankles
  • fast or irregular heartbeat
Captopril + Hydrochlorothiazide may cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Inform your doctor if you have a fever or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Inform your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Captopril + Hydrochlorothiazide with aliskiren (medicine for high blood pressure) if you have diabetes and severe kidney disease.

Do not take this medicine if you are currently taking or have taken sacubitril (medicine for high blood pressure) in the last 36 hours.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • other medicines for high blood pressure e.g. clonidine, propranolol, valsartan
  • water pills or medicines for water retention e.g. spironolactone, amiloride, triamterene
  • medicines for irregular heartbeat e.g. digoxin, procainamide, amiodarone
  • medicines for chest pain e.g. nitroglycerin, isosorbide dinitrate
  • medicines for diabetes e.g. insulin, glibenclamide, glipizide
  • medicines for gout (abnormal metabolism of uric acid) e.g. allopurinol, probenecid
  • cholesterol-lowering medicines e.g. colestyramine, colestipol
  • NSAIDs (medicines for pain and inflammation) e.g. indometacin, diclofenac
  • medicines for mood disorders e.g. lithium, chlorpromazine
  • potassium and calcium supplements (either as a medicine or as a salt substitute)
This list does not include all medicines that may interact with Captopril + Hydrochlorothiazide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Speak to your doctor or dietitian about ways to cut down on your salt intake.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on captopril + hydrochlorothiazide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Sign up for free
Already a member? Sign in