Cefadroxil


Generic Medicine Info
Indications and Dosage
Oral
Skin and skin structure infections, Streptococcal pharyngitis, Tonsillitis, Urinary tract infections
Adult: 1-2 g daily as a single or in 2 divided doses.
Child: ≥6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.
Renal Impairment
Patient on haemodialysis: An additional 0.5-1 g given after each dialysis session.
CrCl (mL/min) Dosage
≤10 0.5-1 g 36 hrly.
11-25 0.5-1 g 24 hrly.
26-50 0.5-1 g 12 hrly.
Hepatic Impairment
No dosage adjustment needed.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Reconstitution
Add the amount of water specified in the container in 2 portions to provide a susp containing 125, 250 or 500 mg per 5 mL. Shake the bottle after each addition.
Contraindications
Hypersensitivity to cefadroxil or to other cephalosporins.
Special Precautions
History of hypersensitivity to penicillins or any other β-lactam drugs. History of GI disease (particularly colitis), severe allergies or asthma. Renal impairment. Pregnancy and lactation.
Adverse Reactions
Dyspepsia, nausea, vomiting, diarrhoea; allergies (e.g. rash, urticaria, angioedema, pruritus); hepatic dysfunction (e.g. cholestasis, elevated serum transaminase); genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Rarely, agranulocytosis, thrombocytopenia, idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, arthralgia.
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Patient Counseling Information
This drug may cause headache, dizziness, nervousness, sleeplessness and fatigue which may impair ability to drive or operate machinery.
MonitoringParameters
Monitor renal function. Observe for signs and symptoms of anaphylaxis during 1st dose.
Overdosage
Symptoms: Nausea, hallucinations, hyperreflexia, extrapyramidal symptoms, clouded consciousness, or even coma and renal function impairment. Management: Induce vomiting at once or gastric lavage; haemodialysis if needed. Monitor and if necessary, correct water and electrolyte balance.
Drug Interactions
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.
Lab Interference
Positive direct Coombs test. False-positive urinary glucose test using cupric sulfate (Benedict's soln, Clinitest®, Fehling's soln). False-positive serum or urine creatinine w/ Jaffe' reaction.
Action
Description: Cefadroxil inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Pharmacokinetics:
Absorption: Almost completely absorbed from the GI tract. Time to peak plasma concentration: 1.5-2 hr.
Distribution: Widely distributed to body tissues and fluids. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 20%.
Excretion: Via urine (more than 90%, as unchanged drug). Plasma half-life: Approx 1.5 hr.
Chemical Structure

Chemical Structure Image
Cefadroxil

Source: National Center for Biotechnology Information. PubChem Database. Cefadroxil, CID=47965, https://pubchem.ncbi.nlm.nih.gov/compound/Cefadroxil (accessed on Jan. 21, 2020)

Storage
Store between 20-25°C. Reconstituted powd for susp: Store between 2-8°C.
MIMS Class
ATC Classification
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
References
Anon. Cefadroxil. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/10/2014.

Buckingham R (ed). Cefadroxil. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/07/2014.

Cefadroxil capsule (Citron Pharma LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.

Cefadroxil, Powder for Suspension (Ranbaxy Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Cefadroxil. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/10/2014.

Wickersham RM. Cefadroxil . Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 07/10/2014.

Disclaimer: This information is independently developed by MIMS based on Cefadroxil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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