Cilamox

Cilamox

amoxicillin

Manufacturer:

Aspen

Distributor:

Luen Cheong Hong (M)
/
Luen Cheong Hong
Concise Prescribing Info
Contents
Amoxicillin trihydrate
Indications/Uses
Infections due to susceptible gram -ve (H. influenza, E. coli, Pr. mirabilis, N. gonorrhoeae) & gram +ve (Streptococcus spp, S. pneumoniae, non-penicillinase producing Staphylococci, Bacillus anthracis) strains.
Dosage/Direction for Use
Upper resp tract infections (due to Streptococci, pneumococci, non-penicillinase producing Stapylococci & H. influenza), GUT infections (due to E. coli, Pr. mirabilis, S. faecalis), skin & skin structure infections Adult 250 mg every 8 hr. Severe infections or those caused be less susceptible organisms: 500 mg every 8 hr. Childn <20 kg 25 mg/kg/day in equally divided doses every 8 hr. Severe infections or those caused by less susceptible organisms: 50 mg/kg/day in equally divided doses every 8 hr. Lower resp tract infections (due to Streptococci, pneumococci, non-penicillinase producing Staphylococci & H. influenzae) Adult 500 mg every 8 hr. Childn <20 kg 50 mg/kg/day in equally divided doses every 8 hr. Urethritis (due to N. gonorrhea) Adult 3 g as single dose. Acute, uncomplicated lower UTI (due to E. coli, Pr. mirabilis, S. faecalis & non-penicillinase producing Staphylococci) Adult 3 g as single dose. Cutaneous anthrax (due to non-penicillinase producing B. anthracis) Adult 500 mg every 8 hr. Childn <20 kg 80 mg/kg/day in equally divided doses every 8 hr. Post-exposure anthrax prophylaxis (due to non-penicillinase producing B. anthracis) Adult 500 mg every 8 hr. Childn <20 kg 80 mg/kg/day in equally divided doses every 8 hr.
Administration
May be taken with or without food: May be taken w/ meals for better absorption & to reduce GI discomfort.
Contraindications
History of allergic reaction to penicillins. Amoxicillin-associated hepatic dysfunction or jaundice.
Special Precautions
Hypersensitvity (anaphylactoid) reactions. Antibiotic-associated pseudomembranous colitis. Periodic assessment of organ system functions including renal, hepatic & hematopoietic function in prolonged therapy. Superinfections w/ mycotic or bacterial pathogens. Not the treatment of choice in patients presenting w/ sore throat or pharyngitis. Infectious mononucleosis. Patients w/ lymphatic leukaemia; evidence of hepatic dysfunction. Moderate or severe renal impairment. May yield false positive result when testing for the presence of glucose in urine using Clinitest, Benedict's soln or Fehling's soln. Concomitant use w/ drugs which delay peristalsis (eg, opiates & diphenoxylate w/ atropine). Lactation.
Adverse Reactions
Diarrhoea, nausea, vomiting, pseudomembranous colitis; erythematous maculopapular rashes, urticaria, erythema multiforme, exfoliative dermatitis; moderate rise in AST; anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia, agranulocytosis.
Drug Interactions
Increased & prolonged blood levels w/ probenecid. Increased incidence of rashes w/ allopurinol & ampicillin; similar reactions can be expected w/ amoxicillin. Reduced effectiveness of OCs. Transient decrease in plasma conc of total conjugated oestriol, oestriol-glucuronide, conjugated oestrone & oestradiol in pregnant women may occur.
MIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cilamox cap 250 mg
Packing/Price
20's
Form
Cilamox cap 500 mg
Packing/Price
20's
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