Cilosol 50/Cilosol 100

Cilosol 50/Cilosol 100

cilostazol

Manufacturer:

Unison

Distributor:

Health Alliance
Concise Prescribing Info
Contents
Cilostazol
Indications/Uses
Improvement of maximal & pain-free walking distances in patients w/ intermittent claudication, w/o rest pain & evidence of peripheral tissue necrosis (peripheral arterial disease Fontaine stage II).
Dosage/Direction for Use
100 mg bd. Patients concomitantly using strong CYP3A4 or CYP2C19 inhibitors Reduce dose to 50 mg bd.
Administration
Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.
Contraindications
Hypersensitivity. Patients w/ CHF; any known predisposition to bleeding (eg, active peptic ulceration, recent hemorrhagic stroke, proliferative diabetic retinopathy, poorly-controlled HTN); QTc prolongation; unstable angina pectoris, MI or coronary intervention w/in the last 6 mth. History of ventricular tachycardia, ventricular fibrillation or multifocal ventricular ectopics; severe tachyarrhythmia. Concomitant use of ≥2 additional antiplatelet or anticoagulant agents (eg, acetylsalicylic acid, clopidogrel, heparin, warfarin, acenocoumarol, dabigatran, rivaroxaban or apixaban). Severe renal impairment (CrCl ≤25 mL/min). Moderate or severe hepatic impairment. Pregnancy.
Special Precautions
Patients at risk for serious cardiac adverse events due to increased heart rate (eg, stable coronary disease). Increased bleeding risk in patients undergoing surgery (including minor invasive measurements like tooth extraction). Exercise caution in patients w/ atrial or ventricular ectopy & atrial fibrillation or flutter. Monitor for any episode of bleeding or easy bruising whilst on therapy; signs suggesting early development of blood dyscrasia eg, pyrexia & sore throat. Pregnancy & lactation.
Adverse Reactions
Headache, diarrhea, abnormal feces. Ecchymosis, edema (peripheral, face), anorexia, dizziness, palpitation, tachycardia, angina pectoris, arrhythmia, ventricular extrasystoles, rhinitis, pharyngitis, nausea & vomiting, dyspepsia, flatulence, abdominal pain, rash, pruritus, chest pain, asthenia.
Drug Interactions
Antiplatelet agents eg, acetylsalicylic acid (ASA), clopidogrel; warfarin; CYP450 inhibitors, substrates, & inducers.
ATC Classification
B01AC23 - cilostazol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Presentation/Packing
Form
Cilosol 100 tab 100 mg
Packing/Price
10 × 10's
Form
Cilosol 50 tab 50 mg
Packing/Price
10 × 10's
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