Glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstruction, CV disease, increased IOP or DM. Elderly ≥60 yr. History of difficulty in swallowing or who have known upper GI narrowing or abnormal esophageal peristalsis. Prevented or diminished positive reactions to dermal reactivity indicators in skin testing procedures. Digitalis, severe liver impairment, pregnancy & lactation. Childn <12 yr.