A colourless, slightly viscous solution containing 0.0568% w/v of clobetasol propionate (equivalent to 0.05% of clobetasol) with methyl paraben 0.1% as preservative.
Pharmacology: Clobetasol has anti-inflammatory, anti-pruritic, and vasoconstrictive actions. When administered topically, particularly under occlusive dressings or when the skin is broken, sufficient corticosteroid may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroids have pharmacological effects or are metabolized. They are metabolized mainly in the liver, also in the kidneys, and are excreted in the urine.
Psoriasis and recalcitrant eczemas of the scalp. Clobetasol is a highly-active topical corticosteroid which is indicated for use in short courses for conditions which do not respond satisfactorily to less active steroids.
Hypersensitivity to the preparation, infections of the scalp, dermatoses in children under one year of age including dermatitis.
Discontinue use if irritation or sensitivity develops. Safety of its use during pregnancy and lactation has not been established. Thus it should be used only if the potential benefit outweighs the potential risk to the foetus or nursing infant. Special care must be taken when giving to paediatric patients as systemic absorption can occur in topical administration causing growth retardation. Caution is advised if the medication is to be applied to extensive surface area. Long-term continuous topical therapy should be avoided. Not suitable for ophthalmic use.
Reported local adverse reactions are burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, maceration of the skin, secondary infection, skin atrophy, striae and miliria. Large doses of corticosteroids may produce symptoms typical of hyperactivity of the adrenal cortex, with moon face, sometimes with hirsutism, buffalo hump, flushing, sometimes leading to a fully developed Cushing's syndrome.
Keep container well closed. Protect from strong light. Store below 30°C.
Recommended shelf-life: 3 years.
Wash and dry affected area. Apply Cloderm Scalp Application sparingly to the affected areas and rub in once or twice daily as directed by the doctor or pharmacist. If symptoms persist please consult the doctor or pharmacist. This preparation is for the treatment of the current condition only. Do not allow use by any other person and dispose of unused material when the treatment is complete.
D07AD01 - clobetasol ; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases.
Scalp application 0.05 % w/v (colourless, slightly viscous solution) x 30 mL.