Initially 20 mg/day as a single dose in the evening. Adjust dosage at 4-wk intervals to a max of 80 mg/day as a single dose in the evening. Hyperlipidaemia
10 mg once daily in the evening. Homozygous familial hypercholesterolaemia
40 mg/day as a single dose in the evening or 80 mg/day in 3 divided doses of 20 mg, 20 mg & a 40 mg dose in the evening. Concomitant therapy
In patients taking cyclosporin, fibrates or niacin concomitantly max: 10 mg/day. Severe renal insufficiency (CrCl <30 mL/min)
Caution w/ dosage >10 mg/day.